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Although clinical descriptions of psychotic patients—especially schizophrenics—date back to at least 1400 b.c., prior to 1950, effective drugs for the treatment of psychotic patients were virtually nonexistent.

Reserpine, an alkaloid, and the active ingredient of Rauwolfia serpentina, the Indian snakeroot, was the basis of the first major tranquilizer.

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Barbiturates (a class of drugs with more effective sedative-hypnotic effects) replaced bromides in 1903.

OFFICIAL NAMES: Major tranquilizers (neuroleptics/antipsychotics): Chlorpromazine (Thorazine); chlorprothixene (Taractan); clozaril (Clozapine); fluphenazine (Permitil, Prolixin); haloperidol (Haldol); loxapine (Daxolin, Loxitane); mesoridazine (Serentil); molindone (Lidone, Moban); olanzapine (Zyprexa); perphenazine (Trilafon); pimozide (Orap); quetiapine (Seroquel); risperidone (Risperdal); thioridazine (Mellaril); thiothixene (Navane); trifluoperazine (Stelazine); trifuluopromazine (Vesprin); ziprasidone (Geodon).

STREET NAMES: Major tranquilizers: antipsychotics, neuroleptics. DRUG CLASSIFICATIONS: Major tranquilizers: Not scheduled OFFICIAL NAMES: Minor tranquilizers (sedative-hypnotics/anxiolytics)/Benzodiazepines: Alprazolam (Xanax); chlordiazepoxide (Librium, Novopoxide); clonazepam (Klonopin); clorazepate (Azene, Tranxene); diazepam (Valium); estazolam (Pro Som); flunitrazepam (Rohypnol/illegal in the United States); flurazepam (Dalmane); halazepam (Paxipam); lorazepam (Ativan); midazolam (Versed); oxazepam (Serax); prazepam (Centrax); quazepam (Doral); temazepam (Restoril); triazolam (Halcion)STREET NAMES: Minor tranquilizers: (benzodiazepines: BZDs, tranks, downers, benzos, goofballs, happy pills, sedative-hypnotics, anxiolytics); (barbiturates: Amys, barbs, blues, downers, yellow jackets, rainbows, red devils); (nonbarbiturate sedative-hypnotics: ludes, Sopors)DRUG CLASSIFICATIONS: Benzodiazepines: Schedule IV, depressants OFFICIAL NAMES: Minor tranquilizers (sedative-hypnotics/anxiolytics)/Nonbenzodiazepines: Zaleplon (Sonata); zolpidem (Ambien); Buspirone (Bu Spar)DRUG CLASSIFICATIONS: Nonbenzodiadepine hypnotics: Zaleplon (Sonata); zolpidem (Ambien), Schedule IV, depressants; Buspirone (Buspar): Not scheduled OFFICIAL NAMES: Minor tranquilizers (sedative-hypnotics/anxiolytics)/ Barbiturates: Amobarbital (Amytal); butabarbital (Butisol); butalbital (Fiorinal, Sedapap); mepho-barbital (Mebaral); methohexital (Brevital); pentobarbital (Nembutal); phenobarbital (Luminal); secobarbital (Seconal)DRUG CLASSIFICATIONS: Barbiturates: Amobarbital (Amytal); butabarbital (Butisol); pentobarbital (Nembutal); secobarbital (Seconal), Schedule II, narcotic analgesics; mepho-barbital (Mebaral); methohexital (Brevital); phenobarbital (Luminal), Schedule IV, narcotic analgesics OFFICIAL NAMES: Minor tranquilizers/Nonbarbiturate sedative-hypnotics: Chloral hydrate (Aquachloral Supprettes, Noctec, Somnos); ethchlorvynol (Placidyl); glutethimide (Doriden); meprobamate (Miltown, Equanil); methaqualone (Quaalude); methyprylon (Noludar)DRUG CLASSIFICATIONS: Nonbarbiturate sedative-hypnotics: Chloral hydrate (Noctec, Somnos), ethchlorvynol (Placidyl), Schedule IV, depressants; glutethimide (Doriden), Schedule II, depressant; meprobamate (Miltown, Equanil), Schedule IV, depressant; methaqualone (Quaalude); methyprylon (Noludar), Schedule I, depressant Tranquilizers are agents that suppress or inhibit some aspects of central nervous system (CNS) activity—the brain, spinal cord, and the nerves from both—and are thus referred to as CNS depressants.

The typical neuroleptics are those that were marketed before 1990.

The atypical or "new generation" neuroleptics work on different neurotransmitters than the older medications.

That is, in order to obtain the same level of intoxication, the tolerant abuser may raise his or her dose to a level that can produce coma and death.