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24-Nov-2017 18:34

Diphenidol (Vontrol), is also an anticholinergic, although little used in the US.

There are also some reports of scopolamine inducing migraine, as well as a withdrawall syndrome.

Histamine (H1-H3) is found diffusely in central vestibular structures and centrally acting antihistamines modulate symptoms of motion sickness (Takeda et al, 1989).

Both the H1 and H2 subtypes of histamine receptors affect vestibular responses (Serafin et al, 1992).

The H3 receptor is an autoreceptor and thus affects H1 and H2.

The circuitry by which several other neurotransmitters affect vestibular responses is less well understood.

Pregnancy category varies from A (controlled human studies have failed to demonstrate a risk to the fetus) through D (there is positive evidence of human fetal risk, use only in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective.

which affect muscarinic receptors, such as scopolamine, increase motion tolerance.

Acetylcholine (ACH) is both a peripheral and central agonist affecting muscarinic receptors, including the vestibular nucleus as well as efferent synapses (Soto et al, 2013).

Receptors found in the pons and medulla, presumably those involved with dizziness, are almost exclusively of the M2 subtype (Barton et al, 1994).

Serotonin receptors are also found in the vestibular nerve and vestibular nucleus (5HT-1, 2 and 7, according to Soto et al, 2013), but the functional significance of this uncertain (Ahn and Balaban, 2010). Withdrawall from serotonergic drugs, such as SSRI antidepressants, is commonly associated with vertigo, and serotonin depletion can cause severe dizziness (Soto et al, 2013).

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