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In 2015, GW Pharmaceuticals and Otsuka Pharmaceuticals announced results of three US Phase 3 trials for the use of Sativex for the treatment of pain in patients with advanced cancer who experience inadequate analgesia during optimized chronic opioid therapy.
According to the results, Sativex did not meet the primary endpoint of demonstrating a statistically significant difference from placebo for pain control.
It may be smoked in "blunts", which are cigars that have been emptied of tobacco and refilled with marijuana, often in combination with another drug, such as crack.
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Marijuana's strength is correlated to the amount of THC it contains and the effects on the user depend on the strength or potency of the THC.
Marijuana contains over 60 different cannabinoid compounds, and overall 400 different compounds have been identified in marijuana, including THC, cannabidiol (CBD), cannabinol, and β-caryophyllene, as noted by the National Institute of Drug Abuse (NIDA).
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